Explain the limitation of In silico prediction tools for genetic variant interptration and classfcation.

Explain the limitation of In silico prediction tools for genetic variant interptration and classfcation.Please see the attached outline. I also will add a useful referances to be used .Referances :https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1353-5#:~:text=The%20ACMG%2FAMP%20guideline%20for%20use%20of%20in%20silico,should%20not%20be%20used%20in%20classifying%20a%20variant.%E2%80%9Dhttps://pubmed.ncbi.nlm.nih.gov/26377032/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870501/