How does each structure/organelle cause human disease?

Pick 5 prokaryotic organelles or structures that you believe are the most important for a bacteria cell to be classified as a human pathogen. For each organelle/structure, explain why these structures increase the pathogenicity or virulence of a bacteria cell towards the human host. How does each structure/organelle cause human disease? What are the cellular or molecular effects on the human cell for each organelle/structure you chose? Number your choices followed by your explanation.