What chromosomal changes took place for this to happen?

http://www-personal.umd.umich.edu/~jcthomas/JCTHOMAS/1997%20Case%20Studies/KS%20Haque1.htmlChoose 1 case study to read
From the link above answer the following questions
-how does this occur? What chromosomal changes took place for this to happen?
-Is it hereditary or familial?
-Main effects from this disorder? Sign/symptoms
-Anything else you feel is relevant
1 page, double spaced, 12pt font. No fluff or filler, just directly to the point is ok.